# co-first authors; *co-senior authors
Biendarra-Tiegs#, S., S. Yechikov#, B. Shergill, K. Takahashi, B. Brumback, V.S. Shirure, L. Houshmand, D. Zhong, K.-C. Weng, J. Silva, T. Smith, S.L. Rentschler, and S.C. George. An iPS-derived In Vitro Model of Human Atrial Conduction. Physiological Reports (DOI: 10.14814/phy2.15407 ), 2022.
Rollins, Z.A., J. Huang, I. Tagkopoulos, R.A. Faller, and S.C. George. A Computational Algorithm to Assess the Physiochemical Determinants of T Cell Receptor Dissociation Kinetics. Computational and Structural Biotechnology Journal 20:3473-3481, 2022.
Rollins, Z.A., R.A. Faller, and S.C. George. Using Molecular Dynamics Simulations to Interrogate T Cell Receptor Non-Equilibrium Kinetics. Computational and Structural Biotechnology Journal 20:2124-2133, 2022.
Glaser D.E., M.D. Curtis, P.A. Sariano, Z.A. Rollins, A. Anand, A.M. Deely, V.S. Shirure, L. Anderson, J.M. Lowen, N.R. Ng, C. Weilbaecher, D.C. Link, and S.C. George. Organ-on-a-chip model of vascularized human bone marrow niches. Biomaterials 280:121245, 2021.
Del Piccolo N, VS Shirure, Y. Bi, S.P. Goedegebuure, S. Gholami, C.C.W. Hughes, R.C. Fields, and S.C. George. Tumor-on-chip modeling of organ-specific cancer and metastasis. Advanced Drug Delivery Reviews 175:113798, 2021.
Yoon PS, Del Piccolo N, Shirure VS, Peng Y, Kirane A, Canter RJ, Fields RC, George SC and Gholami S. Advances in Modeling the Immune Microenvironment of Colorectal Cancer. Front. Immunol. 11:614300, 2021. doi: 10.3389/fimmu.2020.614300
Bi, Y., V.S. Shirure, R. Liu, C. Cunningham, L. Ding, J.M. Meacham, S.P. Goedegebuure, S.C. George*, and R.C. Fields*. Tumor-on-a-chip platform to interrogate the role of macrophages in tumor progression. Integrative Biology (in press), 2020.
Weng, K-C., Y.K. Kurokawa, B.S. Hajek, J.A., Paladin, V.S. Shirure, and S.C. George. Human iPS-Cardiac-Endothelial-Tumor-on-a-Chip to assess anti-cancer efficacy and cardiotoxicity. Tissue Engineering, Part C 26(1):44-55, 2020. 10.1089/ten.TEC.2019.0248. PMC6983745
Hwang, P.Y., A. Brenot, A.C. King, G.D. Longmore*, S.C. George*. Randomly distributed K14+ breast tumor cells polarize to the leading edge to direct collective migration in response to chemical and mechanical environmental cues. Cancer Research, DOI: 10.1158/0008-5472, 2019.
Shirure, V., Y. Bi, M.B. Curtis, A. Lezia, M.M. Goedegebuure, P. Goedegebuure, R. Aft, R.C. Fields*, and S.C. George*. Tumor-on-a-chip platform to investigate progression and drug sensitivity in cell lines and patient-derived organoids. Lab on a Chip, 18:3687-3702, 2018.
Sewell-Loftin, M.K., S.L. Van Hove, E. Crist, T. Hughes, S.M. Joison, G.D. Longmore, and S.C. George. Cancer-associated fibroblasts support vascular growth through mechanical force. Scientific Reports, 7(1):12574, 2017.
Datta, R., C. Heylman, S.C. George*, and E. Gratton*. Label-free imaging of metabolism and oxidative stress in human induced pluripotent stem cell-derived cardiomyocytes. Biomed. Optics Exp, 7(5):1690-701, 2016
Heylman, C, R. Datta, A. Sobrino, S.C. George*, and E. Gratton*. Supervised machine learning for classification of the electrophysiological effects of chronotropic drugs on human induced pluripotent stem cell-derived cardiomyocytes. PLoS One, 10(12): e01445722015, 2015. * contributed equally as senior authors on this manuscript.
Alonzo, L.F., M.L. Moya, V.S. Shirure, and S.C. George. Microfluidic device to control interstitial flow-mediated homotypic and heterotypic cellular communication. Lab on a Chip, 15(17):3521-3529, 2015.
Lee, E.#, Y. Kurokawa#, R. Tu , S.C. George* and M. Khine*. Machine Learning plus Optical flow: A simple and sensitive method to detect cardioactive drugs. Scientific Reports, 5:11817, 2015. #,* contributed equally as first and senior authors, respectively, on this manuscript.
Merna, N., K. Fung, J. Wang, C. King, K. Hansen, K. Christman and S.C. George. Differential β3 Integrin Expression Regulates the Response of Human Lung and Cardiac Fibroblasts to Extracellular Matrix and Its Components. Tiss. Eng. Part A, 21(15-16):2195-2205, 2015.
Heylman, C#., A. Sobrino#, V.S. Shirure#, C.C.W. Hughes, and S.C. George. A strategy for integrating essential 3D microphysiological systems of human organs for realistic anti-cancer drug screening. Exp. Med. and Biol. (in press), 2014. # contributed equally as first authors on this manuscript.
White, S.M., C.R. Pittman, R. Hingorania, R. Arora, T.V. Esipova, S.A. Vinogradov, C.C.W. Hughes, B. Choi*, and S.C. George*. Implanted cell-dense prevascularized spheroids develop functional vasculature that supports reoxygenation following thrombosis. Tiss. Eng. Part A, 10.1089/ten.TEA.2013.0311, 2014.
Moya, M, L.F. Alonzo, and S.C. George. Microfluidic device to culture 3D in vitro Human Capillary Networks. Methods in Molec. Biol.: Biomimetics and Stem Cells Methods and Protocols (edited by G. Vunjak-Novakovic and K. Turksen), 1202:21-27, 2014.
Moya, M#, D. Tran#, and S.C. George. An integrated in vitro model of perfused tumor and cardiac tissue. Stem Cell Res. & Ther., 4 Suppl 1:S15, 2013. # contributed equally as first authors on this manuscript.
Hsu, Y.-H#, M. Moya#, C.C.W. Hughes, S.C. George*, A.P. Lee*. A microfluidic platform for generating large-scale nearly identical human microphysiological system arrays. Lab Chip, 13 (15), 2990 – 2998, 2013. #,*contributed equally as first and corresponding authors, respectively, on this manuscript.
Robertson, C.J., K. Ikemura, T. Krasieva, and S.C. George. Multiscale analysis of collagen microstructure with generalized image correlation spectroscopy and the detection of tissue prestress. Biomaterials 34(26):6127-32, 2013.
Moya, M., Hsu, Y.-H., A.P. Lee*, C.C.W. Hughes*, and S.C. George*. In vitro perfused human capillary networks. Tiss. Engr. Part C, 19(9): 730-737, 2013. (Supplementary video 1, video 2, video 3; Supplementary figure). *contributed equally as corresponding authors on this manuscript.
Zhou, J., M.B. Alvarez-Elizondo, E. Botvinick, and George, S.C.. Adenosine A1 and prostaglandin EP3 receptors mediate global airway contraction following local epithelial injury. Am. J. Resp. Cell Molec. Biol., 48(3):299-305, 2013.
Hsu, Y.-H, M. Moya, C.C.W. Hughes*, S.C. George*, A.P. Lee*. Full range physiological mass transport control in 3D tissue cultures. Lab Chip, 13 (1), 81-89, 2013. *contributed equally as corresponding authors on this manuscript.
Shi, Y., A.S. Aledia, A.V. Tatavoosian, S.C. George, and S.P. Galant. The cut-points for asthma control tests are higher in mexican children in Orange County, California. Ann. Asthma Allergy and Immun, 109(2):108-113, 2012.
White, S.M., R. Hingorania†, R. Aroraa†, C.C.W. Hughes, S.C. George*, and B. Choi*. Longitudinal in vivo imaging to assess blood flow and oxygenation in implantable engineered tissues. Tiss. Engr. Part C, 18(9):697-709, 2012. †contributed equally as authors on this manuscript. *contributed equally as corresponding authors on this manuscript.
Zhou, J., M.B. Alvarez-Elizondo, E. Botvinick, and George, S.C.. Local small airway epithelial injury induces global smooth muscle contraction and airway constriction. J. Appl. Physiol., 112(4):627-637, 2012.
Shi, Y., A.S. Aledia, A. Tatavoosian, S. Vijayalakshmi, S.P. Galant, and George, S.C.. Relating small airways to asthma control by using impulse oscillometry in children. J. Aller. Clin. Immunol., 129(3):671-678, 2012.
Robertson, C.J., S.-W. Lee, Y.-C. Ahn, S. Mahon, Z. Chen, M. Brenner, and S.C. George. Investigating in vivo airway wall mechanics during tidal breathing with optical coherence tomography, J. Biomed. Optics, 16(10):106011, 2011.
White, S.M., S.C. George*, and B. Choi*. Automated computation of functional vascular density using laser speckle imaging in a rodent window chamber model. Microvasc. Res., 82(1):92-5, 2011.*contributed equally as corresponding authors on this manuscript.
Puckett, J.L., R.W.E. Taylor, S.-Y. Leu, O.L. Guijon, A.S. Aledia, S.P. Galant*, and S.C. George*. Clinical patterns in asthma based on proximal and distal airway nitric oxide categories. Resp. Res., 11:47, 2010. *contributed equally as corresponding authors on this manuscript.
Ghajar, C.M., S. Kachgal, E. Kniazeva, H. Mori, S.V. Costes, S.C. George*, and A.J. Putnam*. Mesenchymal cells stimulate capillary morphogenesis via distinct proteolytic mechanisms. Exp. Cell Res. 316(5):813-825, 2010. *contributed equally as corresponding authors on this manuscript.
Raub, C.B., S. Mahon, N. Narula, B.J. Tromberg, M. Brenner, and S.C. George. Linking optics and mechanics in an in vivo model of airway fibrosis and epithelial injury. J. Biomed. Optics., 15(1):015004, 2010.
Puckett, J.L., R.W.E. Taylor, S.-Y. Leu, O.L. Guijon, A.S. Aledia, S.P. Galant*, and S.C. George*. An elevated bronchodilator response predicts large airway inflammation in mild asthma. Ped. Pulm., 45(2):174-181, 2010. *contributed equally as corresponding authors on this manuscript.
Chen, X., A.S. Aledia, S.A. Popson, L. Him, C.C.W. Hughes*, and S.C. George*. Rapid anastomosis of endothelial progenitor cell-derived vessels with host vasculature is promoted by a high density of co-transplanted fibroblasts. Tiss. Eng., 16(2):585-594, 2010.*contributed equally as corresponding authors on this manuscript.
Chen, X., A.S. Aledia, C.M. Ghajar, C.K. Griffith, A.J. Putnam, C.C.W. Hughes, and S.C. George. Prevascularization of a fibrin-based tissue construct accelerates the formation of functional anastomosis with host vasculature. Tiss. Eng., 15(6):1363-1371, 2009.
Suresh, V.*, D.A. Shelley*, H.-W. Shin, and S.C. George. Effect of heterogeneous ventilation and nitric oxide production on exhaled nitric oxide profiles. J. Appl. Physiol., 104:1743-1752, 2008. *contributed equally as 1st authors to this manuscript.
Raub, C.B., J. Unruh, V. Suresh, T. Krasieva, T. Lindmo, E. Gratton, B.J. Tromberg, and S.C. George. Image correlation spectroscopy of multiphoton images correlates with collagen mechanical properties. Biophys. J., 94:2361-2373, 2008.
Shelley, D.A.*, H.-W. Shin*, and S.C. George. In silico modeling of nitric oxide production, transport, and consumption. Drug Disc Today: Dis. Mod.., 4(3):147-53, 2007. *contributed equally as 1st authors to this manuscript.
Raub, C.B, V. Suresh, T. Krasieva, J. Lyubovitsky, J.D. Mih, A.J. Putnam, B.J. Tromberg, and S.C. George. Noninvasive assessment of collagen gel microstructure and mechanics using multiphoton microscopy. Biophys. J., 92:2212-2222, 2007.
Condorelli, P., H-W Shin, A.S. Aledia, P.E. Silkoff, and S.C. George. A simple technique to characterize proximal and peripheral nitric oxide exchange using constant flow exhalations and an axial diffusion model. J. Appl. Physiol., 102:417-425, 2007.
Thompson, H.G.R., J.D. Mih, T.B. Krasieva, B.J. Tromberg, and S.C. George. Epithelial-derived TGF-beta2 modulates basal and wound healing subepithelial matrix homeostasis. Am. J. Physiol. – Lung Cell Molec Physiol., 291:1277-1285, 2006.
Shin, H-W., C.D. Schwindt, A.S. Aledia, C.M Rose-Gottron, J.K. Larson, R.L. Newcomb, D.M. Cooper, and S.C. George. Exercise-induced bronchoconstriction alters airway nitric oxide exchange in a pattern distinct from spirometry. Am. J. Physiol. – Reg. Int. Comp., 291:1741-1748, 2006.
Ghajar, C.M., K.S. Blevins, C.C.W. Hughes, S.C. George, and A.J. Putnam. Mesenchymal Stem cells enhance angiogenesis in mechanically viable prevascularized tissues via early MMP upregulation. Tiss. Engr., 12:2875-2888, 2006.
Shin, H-W., C.M. Rose-Gottron, D.M. Cooper, M. Hill, and S.C. George. Impact of high intensity exercise on flow-independent nitric oxide exchange parameters in healthy adults. Med. Sci. Sport Exer.. 35:995-1003, 2003.
Agarwal, A., J. Mih, and S.C. George. Soluble and fixed protein expression in an in vitro model of airway remodeling in asthma. Allergy Asthma Proceed. 24:35-42, 2003.
Shin, H-W., C. Rose-Gottron, R. Sufi, F. Perez, D. Cooper, A.F. Wilson, and S.C. George. Flow-independent nitric oxide exchange parameters in cystic fibrosis. Am. J. Resp. Crit. Care Med.. 165:349-357, 2002.
Agarwal, A., M. Coleno, W. Wu, C.H. Sun, B.J. Tromberg, and S.C. George. Two-photon laser scanning microscopy of epithelial cell-modulated collagen density in engineered human lung tissue. Tiss. Engr. 7(2):191-202, 2001.
Högman, M, D. Lúdvíksdóttir, S.D. Anderson, S.C. George, L. Håkansson, H.K. Chan, P. Meriläinen, H. Hedenström. Inhaled mannitol shifts exhaled nitric oxide in opposite directions in asthmatics and healthy subjects. Resp. Physiol. 124(2):141-150, 2001.
Tsoukias, N.M. D. Dabdub, A.F. Wilson, and S.C. George. Effect of alveolar volume and sequential filling on the diffusing capacity of the lung: II. experiment. Resp. Physiol. 120(3):250-271, 2000.
Bui, T.D., D. Dabdub, and S.C. George. Modeling the bronchial circulation with application to soluble gas exchange: description and sensitivity analysis. J. Appl. Physiol. 84(6):2070-2088, 1998.