Publications

 

2018

Lam, S.F., V.S. Shirure, Y.E. Chu, A.G Soetikno, and S.C. George.  Microfluidic device to attain high spatial and temporal control of oxygen.  PLoS One (in press), 2018.

Shirure, V., Y. Bi, M.B. Curtis, A. Lezia, M.M. Goedegebuure, P. Goedegebuure, R. Aft, R.C. Fields, and S.C. George. Tumor-on-a-chip platform to investigate progression and drug sensitivity in cell lines and patient-derived organoids. Lab on a Chip, 18:3687-3702, 2018.

Kurokawa, Y.K., M.R. Shang, R.T. Yin, and S.C. George. Modeling trastuzumab-related cardiotoxicity in vitro using human stem cell-derived cardiomyocytes. Tox. Letters 285:74-80, 2018. 

2017

Sewell-Loftin, M.K., S.L. Van Hove, E. Crist, T. Hughes, S.M. Joison, G.D. Longmore, and S.C. George. Cancer-associated fibroblasts support vascular growth through mechanical force.  Scientific Reports, 7(1):12574, 2017.

Traore, M.A. and S.C. George. Tissue Engineering the Vascular Tree. Tissue Engineering, Part B, 23(6):505-514, 2017.

Kurokawa, Y.K., R.T. Yin, M.R. Shang, V.S. Shirure, M.L. Moya, and S.C. George. Human iPS-derived endothelial cells for 3D microphysiological systems. Tissue Engineering, Part C, 23(8):474-484, 2017.

Shirure, V., A. Lezia, A. Tao, L.F. Alonzo, and S.C. George. Low levels of physiological interstitial flow eliminate morphogen gradients and guide angiogenesis. Angiogenesis, 20(4):493-504, 2017.

Shirure, V.S. and S.C. George. ​ Design considerations to minimize the impact of drug absorption in polymer-based organ-on-a-chip platforms. Lab on a Chip, 17, 681 – 690, 2017.​​

2016
Kurokawa, Y. and S.C. George. Tissue engineering the cardiac microenvironment: Multicellular microphysiological systems for drug screening. Adv. Drug Deliv. Rev., 96:225-233, 2016.​

Datta, R., C. Heylman, S.C. George, and E. Gratton. Label-free imaging of metabolism and oxidative stress in human induced pluripotent stem cell-derived cardiomyocytes. Biomed. Optics Exp, 7(5):1690-701, 2016

2015
Heylman, C, R. Datta, A. Sobrino, S.C. George*, and E. Gratton*. Supervised machine learning for classification of the electrophysiological effects of chronotropic drugs on human induced pluripotent stem cell-derived cardiomyocytes. PLoS One, 10(12): e01445722015, 2015.​​​ * contributed equally as senior authors on this manuscript.​​

Alonzo, L.F., M.L. Moya, V.S. Shirure, and S.C. George. Microfluidic device to control interstitial flow-mediated homotypic and heterotypic cellular communication. Lab on a Chip, 15(17):3521-3529, 2015. ​​

Lee, E.#, Y. Kurokawa#, R. Tu , S.C. George* and M. Khine*. Machine Learning plus Optical flow: A simple and sensitive method to detect cardioactive drugs​. Scientific Reports, 5:11817, 2015. #,* contributed equally as first and senior authors, respectively, on this manuscript.​

Merna, N., K. Fung, J. Wang, C. King, K. Hansen, K. Christman and S.C. George. Differential β3 Integrin Expression Regulates the Response of Human Lung and Cardiac Fibroblasts to Extracellular Matrix and Its Components. Tiss. Eng. Part A, 21(15-16):2195-2205, 2015.​

Ehsan, S. and S.C. George. Vessel network formation in response to intermittent hypoxia is frequency dependent. J. Biosci. and Bioeng., 3:347-350, 2015.​​

2014
Ehsan, S., K. Welch, M.L. Waterman, C.C.W. Hughes, and S.C. George. A 3D in vitro model of tumor intravasation. Integrative Biology, 6(6):603-610, 2014.

Heylman, C#., A. Sobrino#, V.S. Shirure#, C.C.W. Hughes, and S.C. George. A strategy for integrating essential 3D microphysiological systems of human organs for realistic anti-cancer drug screening. Exp. Med. and Biol. (in press), 2014. # contributed equally as first authors on this manuscript.

Moya, M, C.C.W. Hughes, and S.C. George. Engineered in vitro systems of the microcirculation. Ch. 7 pg 125-141. In: Vascularization: Regenerative Medicine and Tissue Engineering. CRC Press, 2014.

George, S.C.. Vascularizing engineered tissues for in vivo and in vitro applications. Ch. 11, pg 283-298. In: Cardiac Regeneration and Repair II. Woodhead Publishing series in Biomaterials. 2014.

White, S.M., C.R. Pittman, R. Hingorania, R. Arora, T.V. Esipova, S.A. Vinogradov, C.C.W. Hughes, B. Choi*, and S.C. George*. Implanted cell-dense prevascularized spheroids develop functional vasculature that supports reoxygenation following thrombosis. Tiss. Eng. Part A, 10.1089/ten.TEA.2013.0311, 2014.

Robertson, C., A.E. Heidari, Z. Chen, and S.C. George. Mechanical analysis of arterial plaques in native geometry with OCT wall motion analysis. J. Biomechanics 47:755-758, 2014.

Moya, M. and S.C. George. Integrating in vitro organ-specific function with the microcirculation. Curr Opin Chem Eng 3:102-11, 2014.

Moya, M, L.F. Alonzo, and S.C. George. Microfluidic device to culture 3D in vitro Human Capillary Networks. Methods in Molec. Biol.: Biomimetics and Stem Cells Methods and Protocols (edited by G. Vunjak-Novakovic and K. Turksen), 1202:21-27, 2014.

2013
Moya, M#, D. Tran#, and S.C. George. An integrated in vitro model of perfused tumor and cardiac tissue. Stem Cell Res. & Ther., 4 Suppl 1:S15, 2013. # contributed equally as first authors on this manuscript.

Hsu, Y.-H#, M. Moya#, C.C.W. Hughes, S.C. George*, A.P. Lee*. A microfluidic platform for generating large-scale nearly identical human microphysiological system arrays. Lab Chip, 13 (15), 2990 – 2998, 2013. #,*contributed equally as first and corresponding authors, respectively, on this manuscript.

Robertson, C.J., K. Ikemura, T. Krasieva, and S.C. George. Multiscale analysis of collagen microstructure with generalized image correlation spectroscopy and the detection of tissue prestress. Biomaterials 34(26):6127-32, 2013.

Merna, N., C.R. Robertson, A. La, and S.C. George. Optical imaging predicts mechanical properties during decellularization of cardiac tissue. Tiss Engr. Part C, 19(10): 802-9, 2013.

Ehsan, S and S.C. George. Non-steady state oxygen transport in engineered tissue: Implications for design. Tiss Engr. Part A 19(11-12):1433-1442, 2013.

Raub, C.B., B.J. Tromberg, and S.C. George. Second-harmonic generation imaging of self-assembled collagen gels. Second Harmonic Generation Imaging. Chapter 11. (in press), 2013.

Moya, M., Hsu, Y.-H., A.P. Lee*, C.C.W. Hughes*, and S.C. George*. In vitro perfused human capillary networks. Tiss. Engr. Part C, 19(9): 730-737, 2013. (Supplementary video 1, video 2, video 3; Supplementary figure). *contributed equally as corresponding authors on this manuscript.

Robertson, C.J., D. Tran, and S.C. George. Maturation phases of human pluripotent stem cell-derived cardiomyocytes. Stem Cells 31:829-837, 2013.

Zhou, J., M.B. Alvarez-Elizondo, E. Botvinick, and George, S.C.. Adenosine A1 and prostaglandin EP3 receptors mediate global airway contraction following local epithelial injury. Am. J. Resp. Cell Molec. Biol., 48(3):299-305, 2013.

Hsu, Y.-H, M. Moya, C.C.W. Hughes*, S.C. George*, A.P. Lee*. Full range physiological mass transport control in 3D tissue cultures. Lab Chip, 13 (1), 81-89, 2013. *contributed equally as corresponding authors on this manuscript.

Shi, Y., A.S. Aledia, S.P. Galant, and George, S.C. Peripheral airway impairment measured by oscillometry predicts loss of asthma control in children. J. Aller. Clin. Immunol., 131(3):718-723, 2013.

2012
Robertson, C.J. and S.C. George. Theory and practical recommendations for autocorrelation-based image correlation spectroscopy. J. Biomed. Optics, 17, 080801 (2012).

Shi, Y., A.S. Aledia, A.V. Tatavoosian, S.C. George, and S.P. Galant. The cut-points for asthma control tests are higher in mexican children in Orange County, California. Ann. Asthma Allergy and Immun, 109(2):108-113, 2012.

White, S.M., R. Hingorania†, R. Aroraa†, C.C.W. Hughes, S.C. George*, and B. Choi*. Longitudinal in vivo imaging to assess blood flow and oxygenation in implantable engineered tissues. Tiss. Engr. Part C, 18(9):697-709, 2012. †contributed equally as authors on this manuscript. *contributed equally as corresponding authors on this manuscript.

Gelb, A.F., P.J. Barnes, S.C. George, F.L.M. Ricciardolo, G. DiMaria, and N. Zamel. Review of exhaled nitric oxide in chronic obstructive pulmonary disease. J. Breath Res. 6 (2012) 047101. 2012.

Zhou, J., M.B. Alvarez-Elizondo, E. Botvinick, and George, S.C.. Local small airway epithelial injury induces global smooth muscle contraction and airway constriction. J. Appl. Physiol., 112(4):627-637, 2012.

Shi, Y., A.S. Aledia, A. Tatavoosian, S. Vijayalakshmi, S.P. Galant, and George, S.C.. Relating small airways to asthma control by using impulse oscillometry in children. J. Aller. Clin. Immunol., 129(3):671-678, 2012.

2011
George, S.C. and M.P. Hlastala. Airway Gas Exchange and Exhaled Biomarkers. Comprehensive Physiol., 1:1837-1859, 2011.

Tian, L., and S.C. George. Biomaterials to vascularize engineered tissues. J. Cardio. Trans. Res., 4(5):685-98, 2011.

Robertson, C.J., S.-W. Lee, Y.-C. Ahn, S. Mahon, Z. Chen, M. Brenner, and S.C. George. Investigating in vivo airway wall mechanics during tidal breathing with optical coherence tomography, J. Biomed. Optics, 16(10):106011, 2011.

Jiang, J. and S.C. George. TGF-β2 reduces nitric oxide synthase mRNA through a ROCK-dependent pathway in airway epithelial cells. Am. J. Physiol.: Lung Cell Molec. Biol., 301(3):L361-7, 2011.

Jiang, J. and S.C. George. Modeling gas phase nitric oxide release in lung epithelial cells. Nitric Oxide: Biol. Chem., 25(3):275-81, 2011.

White, S.M., S.C. George*, and B. Choi*. Automated computation of functional vascular density using laser speckle imaging in a rodent window chamber model. Microvasc. Res., 82(1):92-5, 2011.*contributed equally as corresponding authors on this manuscript.

2010
Raub, C.B., B.J. Tromberg, A. Putnam, and S.C. George. Predicting bulk mechanical properties of cellularized collagen gels using multiphoton microscopy. Acta Biomaterialia., 6:4657-4665, 2010.

Puckett, J.L., R.W.E. Taylor, S.-Y. Leu, O.L. Guijon, A.S. Aledia, S.P. Galant*, and S.C. George*. Clinical patterns in asthma based on proximal and distal airway nitric oxide categories. Resp. Res., 11:47, 2010. *contributed equally as corresponding authors on this manuscript.

Miller, C., S.C. George, and L.A. Niklason. Developing a tissue engineered model of the human bronchiole. J. Tiss. Eng. Regen. Med., 4(8):619-27, 2010.

Shelley, D.A., J.L. Puckett, and S.C. George. Quantifying proximal and distal sources of NO using a multi-compartment model. J. Appl. Physiol., 108(4):821-829, 2010.

Ghajar, C.M., S. Kachgal, E. Kniazeva, H. Mori, S.V. Costes, S.C. George*, and A.J. Putnam*. Mesenchymal cells stimulate capillary morphogenesis via distinct proteolytic mechanisms. Exp. Cell Res. 316(5):813-825, 2010. *contributed equally as corresponding authors on this manuscript.

Raub, C.B., S. Mahon, N. Narula, B.J. Tromberg, M. Brenner, and S.C. George. Linking optics and mechanics in an in vivo model of airway fibrosis and epithelial injury. J. Biomed. Optics., 15(1):015004, 2010.

Puckett, J.L., R.W.E. Taylor, S.P. Galant, and S.C. George. Impact of analysis interval on the multiple exhalation flow technique to partition exhaled nitric oxide. Ped. Pulm., 45(2):182-191, 2010.

Puckett, J.L., R.W.E. Taylor, S.-Y. Leu, O.L. Guijon, A.S. Aledia, S.P. Galant*, and S.C. George*. An elevated bronchodilator response predicts large airway inflammation in mild asthma. Ped. Pulm., 45(2):174-181, 2010. *contributed equally as corresponding authors on this manuscript.

Chen, X., A.S. Aledia, S.A. Popson, L. Him, C.C.W. Hughes*, and S.C. George*. Rapid anastomosis of endothelial progenitor cell-derived vessels with host vasculature is promoted by a high density of co-transplanted fibroblasts. Tiss. Eng., 16(2):585-594, 2010.*contributed equally as corresponding authors on this manuscript.

2009
Griffith, C.K. and S.C. George. The effect of hypoxia on in vitro prevascularization of a thick soft tissue. Tiss. Eng. 15(9):2423-2434, 2009.

Arold, S.P., N. Malavia, and S.C. George. Mechanical compression attenuates normal human bronchial epithelial wound healing . Resp. Res., 10:9, 2009.

Jiang, J., N. Malavia, V. Suresh, and S.C. George. Nitric oxide gas phase release in human small airway epithelial cells. Resp. Res., 10:3, 2009.

Malavia, N, C.B. Raub, S.B. Mahon, M. Brenner, R.A. Panettieri, and S.C. George. Airway epithelium stimulates smooth muscle proliferation. Am. J. Resp. Cell Molec. Biol., 41(3):297-304, 2009.

Chen, X., A.S. Aledia, C.M. Ghajar, C.K. Griffith, A.J. Putnam, C.C.W. Hughes, and S.C. George. Prevascularization of a fibrin-based tissue construct accelerates the formation of functional anastomosis with host vasculature. Tiss. Eng., 15(6):1363-1371, 2009.

2008
Puckett, J.L. and S.C. George. Partitioned exhaled nitric oxide to non-invasively assess asthma. Resp. Physiol. Neurobiol., 163:166-177, 2008.

Ghajar, C.M., S.C. George, and A.J. Putnam. Matrix metalloproteinase control of capillary morphogenesis. Crit Rev Eukaryot Gene Expr. 2008 ; 18(3): 251?278.​

George, S.C. How accurately should we estimate the anatomical source of exhaled nitric oxide? (editorial) J. Appl. Physiol., 104:909-991, 2008.

Suresh, V.*, D.A. Shelley*, H.-W. Shin, and S.C. George. Effect of heterogeneous ventilation and nitric oxide production on exhaled nitric oxide profiles. J. Appl. Physiol., 104:1743-1752, 2008. *contributed equally as 1st authors to this manuscript.

Malavia, N, J.D. Mih, C.B. Raub, B.T. Dinh, and S.C. George. IL-13 induces a bronchial epithelial phenotype that is profibrotic. Resp. Res., 9:27, 2008.

Raub, C.B., J. Unruh, V. Suresh, T. Krasieva, T. Lindmo, E. Gratton, B.J. Tromberg, and S.C. George. Image correlation spectroscopy of multiphoton images correlates with collagen mechanical properties. Biophys. J., 94:2361-2373, 2008.

Ghajar, C.M., X. Chen, J.W. Harris, V. Suresh, C.C.W. Hughes, N.L. Jeon, A.J. Putnam, and S.C. George. The effect of matrix density on 3-D capillary morphogenesis. Biophys. J., 94:1930-1941, 2008.

2007
Shelley, D.A.*, H.-W. Shin*, and S.C. George. In silico modeling of nitric oxide production, transport, and consumption. Drug Disc Today: Dis. Mod.., 4(3):147-53, 2007. *contributed equally as 1st authors to this manuscript.

Suresh, V., J.D. Mih, and S.C. George. Measurement of IL-13-induced iNOS-derived gas phase nitric oxide in human bronchial epithelial cells. Am. J. Resp. Cell Molec. Biol., 37:97-104, 2007.

Ghajar, C.M., V. Suresh, S.R. Peyton, C.B. Raub, S.C. George, and A.J. Putnam. A Novel 3-D Model to Quantify Metastatic Melanoma Invasion. Molec. Cancer Ther., 6(2):552-561, 2007.

Raub, C.B, V. Suresh, T. Krasieva, J. Lyubovitsky, J.D. Mih, A.J. Putnam, B.J. Tromberg, and S.C. George. Noninvasive assessment of collagen gel microstructure and mechanics using multiphoton microscopy. Biophys. J., 92:2212-2222, 2007.

Shin, H-W., D.A. Shelley, A. Fitzpatrick, B. Gaston, and S.C. George. Airway nitric oxide is reduced following phosphate buffered saline inhalation in asthma. J. Appl. Physiol., 102:1028-1032, 2007.

Condorelli, P., H-W Shin, A.S. Aledia, P.E. Silkoff, and S.C. George. A simple technique to characterize proximal and peripheral nitric oxide exchange using constant flow exhalations and an axial diffusion model. J. Appl. Physiol., 102:417-425, 2007.

Thompson, H.G.R., D.T. Truong, C. Griffith, and S.C. George. A three-dimensional in vitro model of angiogenesis in the airway mucosa. Pulm. Pharm. Therap., 20:141-148, 2007.

2006
Thompson, H.G.R., J.D. Mih, T.B. Krasieva, B.J. Tromberg, and S.C. George. Epithelial-derived TGF-beta2 modulates basal and wound healing subepithelial matrix homeostasis. Am. J. Physiol. – Lung Cell Molec Physiol., 291:1277-1285, 2006.

Shin, H-W., C.D. Schwindt, A.S. Aledia, C.M Rose-Gottron, J.K. Larson, R.L. Newcomb, D.M. Cooper, and S.C. George. Exercise-induced bronchoconstriction alters airway nitric oxide exchange in a pattern distinct from spirometry. Am. J. Physiol. – Reg. Int. Comp., 291:1741-1748, 2006.

Ghajar, C.M., K.S. Blevins, C.C.W. Hughes, S.C. George, and A.J. Putnam. Mesenchymal Stem cells enhance angiogenesis in mechanically viable prevascularized tissues via early MMP upregulation. Tiss. Engr., 12:2875-2888, 2006.

Shin, H-W., P. Condorelli, and S.C. George. Examining axial diffusion of nitric oxide in the lungs using heliox and breathhold. J. Appl. Physiol., 100:623-630, 2006.

2005
Shin, H-W., P. Condorelli, and S.C. George. A new and more accurate technique to characterize airway nitric oxide using different breathhold times. J. Appl. Physiol. 98:1869-1877, 2005.

Griffith, C.K., C. Miller, R.C.A Sainson, J.W. Calvert, N.L. Jeon, C.C.W. Hughes, S.C. George. Diffusion limits of an in vitro thick prevascularized tissue. Tiss. Engr. 11:257-266, 2005.

2004
Shin, H-W., P. Condorelli, C.M Rose-Gottron, D.M. Cooper, and S.C. George. Probing the impact of axial diffusion on nitric oxide exchange using heliox.. J. Appl. Physiol. 97:874-882, 2004.

Condorelli, P., H-W. Shin, and S.C. George. Characterizing airway and alveolar nitric oxide exchange during tidal breathing using a three-compartment model. J. Appl. Physiol. 96:1832-1834, 2004.

George, S.C., M. Hogman, S. Permutt, and P.E. Silkoff. Modeling pulmonary nitric oxide exchange. J. Appl. Physiol. 96:831-839, 2004.

Shin, H-W., C.M. Rose-Gottron, D.M. Cooper, R.L. Newcomb, and S.C. George. Airway diffusing capacity of nitric oxide and steroid therapy in asthma. J. Appl. Physiol., 96:65-75, 2004.

Jeh, H. and S.C. George. Encapsulation of PROLI/NO in biodegradable microparticles. J. Microencap.. 21(1):3-13, 2004.

2003
Shin, H-W., C.M. Rose-Gottron, D.M. Cooper, M. Hill, and S.C. George. Impact of high intensity exercise on flow-independent nitric oxide exchange parameters in healthy adults. Med. Sci. Sport Exer.. 35:995-1003, 2003.

Agarwal, A., J. Mih, and S.C. George. Soluble and fixed protein expression in an in vitro model of airway remodeling in asthma. Allergy Asthma Proceed. 24:35-42, 2003.

2002
Shin, H-W. and S.C. George. Impact of axial diffusion on nitric oxide exchange in the lungs. J. Appl Physiol 93:2070-2080, 2002.

Condorelli, P. and S.C. George. Free nitric oxide diffusion in the bronchial microcirculation. Am. J.. Physiol. 283:H2660-H2670, 2002.

Jeh, H. and S.C. George. Dynamic modeling of nitric oxide delivery to pulmonary arterioles. Ann. Biomed. Engr. 30:1-15, 2002.

Shin, H-W., C. Rose-Gottron, R. Sufi, F. Perez, D. Cooper, A.F. Wilson, and S.C. George. Flow-independent nitric oxide exchange parameters in cystic fibrosis. Am. J. Resp. Crit. Care Med.. 165:349-357, 2002.

2001
Shin, H-W., C. Rose-Gottron, F. Perez, D. Cooper, A.F. Wilson, and S.C. George. Flow-independent nitric oxide exchange parameters in healthy adults. J. Appl. Physiol.. 91:2173-2181, 2001.

Kwon, S. and S.C. George. Mechanisms of synergistic cytokine-induced nitric oxide production in human alveolar epithelial cells. Nitric Oxide: Biol. Chem. 5(6):534-546, 2001.

Tsoukias, N.M., H-W. Shin, A.F. Wilson, and S.C. George. A single breath technique with variable flow rate to characterize NO exchange dynamics in the lungs. J. Appl. Physiol.. 91:477-487, 2001.

Tsoukias, N.M., and S.C. George. Impact of volume-dependent diffusing capacity on exhaled nitric oxide concentration. Ann. Biomed. Engr. 29(9):731-739, 2001.

Condorelli, P. and S.C. George. A kinetic analysis of soluble guanylate cyclase activation by free nitric oxide. Biophys. J. 80:2110-2119, 2001.

Agarwal, A., M. Coleno, W. Wu, C.H. Sun, B.J. Tromberg, and S.C. George. Two-photon laser scanning microscopy of epithelial cell-modulated collagen density in engineered human lung tissue. Tiss. Engr. 7(2):191-202, 2001.

Shin, H-W. and S.C. George. Microscopic modeling of nitric oxide and S-nitrosoglutathione kinetics and transport in human airways. J. Appl. Physiol. 90(3):777-788, 2001.

Högman, M, D. Lúdvíksdóttir, S.D. Anderson, S.C. George, L. Håkansson, H.K. Chan, P. Meriläinen, H. Hedenström. Inhaled mannitol shifts exhaled nitric oxide in opposite directions in asthmatics and healthy subjects. Resp. Physiol. 124(2):141-150, 2001.

2000
Tsoukias, N.M. D. Dabdub, A.F. Wilson, and S.C. George. Effect of alveolar volume and sequential filling on the diffusing capacity of the lung: II. experiment. Resp. Physiol. 120(3):250-271, 2000.

Tsoukias, N.M., A.F. Wilson, and S.C. George. Effect of alveolar volume and sequential filling on the diffusing capacity of the lung: I. theory. Resp. Physiol. 120(3):231-249, 2000.

1999
Kwon, S. and S.C. George. Synergistic cytokine-induced nitric oxide production in human alveolar epithelial cells. Nitric Oxide: Biol. Chem. 3(4):348-357,1999.

Condorelli, P. and S.C. George. Theoretical determination of gas phase mass transfer coefficients for endogenously produced gases in the human airways. Ann. Biomed. Engr. 27(3):326-339, 1999.

1998
Tsoukias, N.M. and S.C. George. A two-compartment model of pulmonary nitric oxide exchange dynamics. J. Appl. Physiol. 85(2):653-666, 1998.

Tsoukias, N.M., Z. Tannous, A.F. Wilson, and S.C. George. Single exhalation profiles of NO And CO2 in humans: effect of dynamically changing flow rate. J. Appl. Physiol. 85(2):642-652, 1998.

Bui, T.D., D. Dabdub, and S.C. George. Modeling the bronchial circulation with application to soluble gas exchange: description and sensitivity analysis. J. Appl. Physiol. 84(6):2070-2088, 1998.​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​

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